Absin多重荧光免疫组化服务

· Absin是国内首批多色平台之一丰富的项目经验和指标验证经验；

· 拥有优秀的软硬件设施，定量分析采用数字病理金标准分析平台HALO软件；

· 资深多色团队共同服务客户，为您提供常见免疫微环境panel推荐、抗体推荐、项目探讨等售前售后咨询服务。

【爱必信多色服务】

我们可以提供的服务：

最多六指标七色（含DAPI）的多重荧光免疫组化服务，样本种属涵盖人、小鼠、大鼠、猪等；组织类型以肿瘤样本居多，涵盖肺、胃、肝、肾、肠等各大器官，甲状腺、胰腺、唇腺、泪腺等各大腺体，另还有眼球、神经、大脑等特殊样本；切片类型涵盖石蜡切片、组织芯片（TMA）、冰冻切片等，并提供全片扫描和定量分析。

个性化服务（先做预实验，实验有保障，结果更完美！）

标准化检测（高性价比，已优化过条件，只需提供样本，直接出实验结果！强烈推荐！）

【订购信息】

           单阳性细胞占有核细胞百分比，密度。

           多阳性细胞占有核细胞百分比，密度。

           组织面积和特定病理形态面积计算。

           TMA提供每个芯点的以上定量结果，并提供热图。

黑色素瘤组织,CD8,PD1,S100,Sox10,PD-1药物抗性及病人复发机制

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刘佳楠,马曌磊,苏荣健,黄克强.zeste基因增强子同源物2抑制剂GSK126对舌鳞状细胞癌细胞增殖与凋亡的影响[J].华西口腔医学杂志,2020,38(05):495-501.

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Qi L, Hu H, Wang Y, Hu H, Wang K, Li P, Yin J, Shi Y, Wang Y, Zhao Y, Lyu H, Feng M, Xue M, Li X, Li Y, Yan S. New insights into the central sympathetic hyperactivity post-myocardial infarction: Roles of METTL3-mediated m6 A methylation. J Cell Mol Med. 2022 Feb;26(4):1264-1280. doi: 10.1111/jcmm.17183. Epub 2022 Jan 17. PMID: 35040253; PMCID: PMC8831944.

汪新芳,马滕.雷公藤甲素对急性高眼压大鼠视网膜神经节细胞的保护作用[J].中国医药导报,2021,18(18):13-16+198.

Li TJ, Jin KZ, Li H, Ye LY, Li PC, Jiang B, Lin X, Liao ZY, Zhang HR, Shi SM, Lin MX, Fei QL, Xiao ZW, Xu HX, Liu L, Yu XJ, Wu WD. SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer. Cancer Lett. 2022 Apr 1;530:142-155. doi: 10.1016/j.canlet.2022.01.026. Epub 2022 Jan 22. PMID: 35077803.

Chen L, Hu Y, Wang S, Cao K, Mai W, Sha W, Ma H, Zeng LH, Xu ZZ, Gao YJ, Duan S, Wang Y, Gao Z. mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight. 2022 Oct 4:e159247. doi: 10.1172/jci.insight.159247. Epub ahead of print. PMID: 36194480.

李扬,刘国良,姚远,张宁,郭玮.杜仲总黄酮对小儿血管瘤内皮细胞凋亡的影响[J].中国医药导报,2017,14(24):21-24.

Zhang QY, Ye XP, Zhou Z, Zhu CF, Li R, Fang Y, Zhang RJ, Li L, Liu W, Wang Z, Song SY, Lu SY, Zhao SX, Lin JN, Song HD. Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto's thyroiditis. Nat Commun. 2022 Feb 9;13(1):775. doi: 10.1038/s41467-022-28120-2. PMID: 35140214; PMCID: PMC8828859.

Yang M, Yu H, Yu X, Liang S, Hu Y, Luo Y, Izsvák Z, Sun C, Wang J. Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells. Cell Stem Cell. 2022 Mar 3;29(3):400-418.e13. doi: 10.1016/j.stem.2022.01.010. Epub 2022 Feb 9. PMID: 35143761.

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Mi Z, Wang Z, Xue X, Liu T, Wang C, Sun L, Yu G, Zhang Y, Shi P, Sun Y, Yang Y, Ma S, Wang Z, Yu Y, Liu J, Liu H, Zhang F. The immune-suppressive landscape in lepromatous leprosy revealed by single-cell RNA sequencing. Cell Discov. 2022 Jan 11;8(1):2. doi: 10.1038/s41421-021-00353-3. PMID: 35013182; PMCID: PMC8748782.

Yan Z, Da Q, Li Z, Lin Q, Yi J, Su Y, Yu G, Ren Q, Liu X, Lin Z, Qu J, Yin W, Liu J. Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis. Front Oncol. 2022 Feb 10;12:812655. doi: 10.3389/fonc.2022.812655. PMID: 35223495; PMCID: PMC8866693.

Li J, Yan S, Li Q, Huang Y, Ji M, Jiao X, Yuan M, Wang G. Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis. Mol Hum Reprod. 2022 Apr 29;28(5):gaac010. doi: 10.1093/molehr/gaac010. PMID: 35404426.

Wang K, You S, Hu H, Li X, Yin J, Shi Y, Qi L, Li P, Zhao Y, Yan S. Effect of TLR4/MyD88/NF-kB axis in paraventricular nucleus on ventricular arrhythmias induced by sympathetic hyperexcitation in post-myocardial infarction rats. J Cell Mol Med. 2022 May;26(10):2959-2971. doi: 10.1111/jcmm.17309. Epub 2022 Apr 8. PMID: 35393774; PMCID: PMC9097841.

Yang H, Sun B, Fan L, Ma W, Xu K, Hall SRR, Wang Z, Schmid RA, Peng RW, Marti TM, Gao W, Xu J, Yang W, Yao F. Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma. Theranostics. 2022 Mar 28;12(7):3104-3130. doi: 10.7150/thno.69590. PMID: 35547750; PMCID: PMC9065207.

Guan X, Sun L, Shen Y, Jin F, Bo X, Zhu C, Han X, Li X, Chen Y, Xu H, Yue W. Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis. Nat Commun. 2022 May 20;13(1):2834. doi: 10.1038/s41467-022-30543-w. PMID: 35595770; PMCID: PMC9123179.

Jin Z, Chang B, Wei Y, Yang Y, Zhang H, Liu J, Piao L, Bai L. Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy. Biomed Pharmacother. 2022 Jul;151:113092. doi: 10.1016/j.biopha.2022.113092. Epub 2022 May 10. PMID: 35550528.

Ye B, Lu Z. Role of TRIM22 in ulcerative colitis and its underlying mechanisms. Mol Med Rep. 2022 Aug;26(2):249. doi: 10.3892/mmr.2022.12765. Epub 2022 Jun 8. PMID: 35674157; PMCID: PMC9218723.

Jiang XP, Sun YX, Qiao B, Zhu WJ, Chu YJ, Sun MM, Tang RJ, Ma TL, Tang ZA. Youjing granules ameliorate spermatogenesis in rats through regulating the prolifereation of spermatogonial stem cells. Chin J Nat Med. 2022 Aug;20(8):580-588. doi: 10.1016/S1875-5364(22)60209-7. PMID: 36031230.

Huang W, Wang BO, Hou YF, Fu Y, Cui SJ, Zhu JH, Zhan XY, Li RK, Tang W, Wu JC, Wang ZY, Wang M, Wang XJ, Zhang Y, Liu M, Xie YS, Sun Y, Yi F. JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism. JCI Insight. 2022 Jun 16;7(14):e158571. doi: 10.1172/jci.insight.158571. PMID: 35708906; PMCID: PMC9431718.

Cui WW, Ye C, Wang KX, Yang X, Zhu PY, Hu K, Lan T, Huang LY, Wang W, Gu B, Yan C, Ma P, Qi SH, Luo L. Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction. Front Cardiovasc Med. 2022 Apr 18;9:864188. doi: 10.3389/fcvm.2022.864188. PMID: 35509278; PMCID: PMC9058095.

Huang H, Ye L, Li S, Luo X, wu y. Construction of an active immune model and electrophysiological study of mice with anti-NMDAR encephalitis. Research Square; 2022. DOI: 10.21203/rs.3.rs-1509233/v1.

Cui K, Yao S, Liu B, Sun S, Gong L, Li Q, Fei B, Huang Z. A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer. Br J Cancer. 2022 Nov;127(8):1450-1460. doi: 10.1038/s41416-022-01936-x. Epub 2022 Aug 8. PMID: 35941174; PMCID: PMC9553888.

Fei X, Wu X, Dou YN, Sun K, Guo Q, Zhang L, Li S, Wei J, Huan Y, He X, Fei Z. TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I. Mol Ther Oncolytics. 2022 Aug 25;26:413-428. doi: 10.1016/j.omto.2022.08.007. PMID: 36159777; PMCID: PMC9465028.

Han X, Zhang Y, Li Y, Lin Z, Pei X, Feng Y, Yang J, Li F, Li T, Fu Z, Wang C, Li C. Pyrotinib Targeted EGFR-STAT3/CD24 Loop-Mediated Cell Viability in TSC. Cells. 2022 Sep 29;11(19):3064. doi: 10.3390/cells11193064. PMID: 36231025; PMCID: PMC9563285.

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