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- 品牌：爱必信(absin)
- 产地：上海
- 型号：50ug，100ug
- 货号：abs130481
- 价格： ￥1500/支
- 发布日期： 2019-10-25
- 更新日期： 2025-03-28
| 产地 | 上海 |
| 品牌 | 爱必信(absin) |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 货号 | abs130481 |
| 用途 | - |
| 应用范围 | - |
| 抗原来源 | - |
| 保质期 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 抗体名 | Nrf2抗体 |
| 靶点 | Nrf2 |
| 适应物种 | Human, Mouse, Rat |
| 形态 | - |
| 宿主 | Rabbit |
| 标记物 | - |
| 包装规格 | 50ug，100ug |
| 亚型 | - |
| 标识物 | - |
| 浓度 | 1mg/ml% |
| 免疫原 | A synthesized peptide derived from Human NFE2L2(Accession Q16236), corresponding to amino acid residues I28-L48. |
| 是否进口 | 否 |
| 描述 |
GABPA Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Belongs to the ETS family. Heterotetramer of two alpha and two beta subunits.
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| 别名 |
Nrf2抗体;erythroid derived 2, HEBP1, like 2, NF E2 related factor 2, NF-E2-related factor 2, NF2L2_HUMAN, NFE2 related factor 2, NFE2-related factor 2, Nfe2l2, Nrf 2, NRF2, Nuclear factor (erythroid derived 2) like 2, Nuclear factor, nuclear factor erythroid 2 like 2, Nuclear factor erythroid 2 related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2,
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| 宿主 |
Rabbit
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| 特异性 |
Nrf2 Antibody detects endogenous levels of Nrf2.
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| 反应种属 |
Human;Mouse;Rat
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| 应用 |
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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| 分子量 |
Predicted molecular weight: 68kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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| 免疫原 |
A synthesized peptide derived from Human NFE2L2(Accession Q16236), corresponding to amino acid residues I28-L48.
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| 性能 | |
| 浓度 |
1mg/ml
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| 纯化方法 |
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
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| 类型 |
Polyclonal Antibody
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| 储存/保存方法 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
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| 存储溶液 |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
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| 靶标 | |
| 背景说明 |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
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| 组织特异性 |
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
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| 翻译后修饰 |
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence.Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane.
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| 细胞定位 |
Cytoskeleton;Cytosol;Golgi apparatus;Nucleus;Plasma Membrane;
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| UniProt |
Q16236
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