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荧光染色试剂描述：

中文名称：coumarin-Suberoylanilide Hydroxamic Acid;

英文名称：coumarin-SAHA

CAS：1260635-77-5

纯度：≥98%

外观：

分子量：346.4

分子式：无

C₁₈H₂₂N₂O₅

光谱特性：

产品描述：Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.¹ coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. ² The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.² This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.

应用：

保存方法：Store at -20℃

溶解性：

mdl号：

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