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荧光染色试剂描述：

中文名称：N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine

英文名称：TPEN

CAS：16858-02-9

纯度：≥97%

外观：Powder

分子量：424.54

分子式：无

C₂₆H₂₈N₆

光谱特性：

产品描述：TPEN is a cell permeable, high-affinity heavy metal (Zn²⁺>Fe²⁺>Mn²⁺) chelator that exhibits low affinity for Mg²⁺ and Ca²⁺. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 in biophysical studies of Ca²⁺.

应用：An apoptosis inducer and heavy metal chelator

保存方法：Store at 4° C

溶解性：Soluble in ethanol (~20 mg/ml), DMF (~1 mg/ml), DMSO (~0.15 mg/ml), methanol, chloroform, PBS, and 1:10 solution of ethanol:PBS (pH 7.2) (~0.1 mg/ml). Insoluble in water.

mdl号：MFCD00036918

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