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爱必信产品描述：

中文名称：(3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

英文名称：(3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

CAS：1161002-05-6

纯度：≥95%

别名：见爱必信官网

来源：见爱必信官网

产品描述：

G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens.¹ It is thought to be involved in estrogen-sensitive cancers.^1,2 GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth.¹ G-15 is a cell-permeable non-steroidal antagonist of GPER (K_i = 20 nM).³ It displays low affinity cross-reactivity with the classical estrogen receptor (ER), ERα, so that at doses greater than 1 µM it is capable of mediating limited ER-dependent transcriptional activity.⁴ G-15 antagonizes the anti-depressive effects of estrogen in vivo.³

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