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爱必信产品描述：

中文名称：磷酸吡哆醛-6-偶氮(苯-2,4-二磺酸)四钠盐水合物

英文名称：Pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt hydrate

CAS：192575-19-2

纯度：≥95%

别名：Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid;

来源：见爱必信官网

产品描述：

P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P₂ purinergic antagonist that blocks recombinant P2X_1-5 (IC₅₀s = 1-2.6 μM), native P2Y₂-like (IC₅₀ = ~0.9 mM), and recombinant P2Y₄ (IC₅₀ = ~15 mM) receptors.¹ PPADS antagonism of ATP-sensitive P₂ receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.²

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