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爱必信产品描述：

中文名称：S32826 disodium salt hydrate

英文名称：S32826 disodium salt hydrate

CAS：1096770-84-1

纯度：≥98%

别名：见爱必信官网

来源：见爱必信官网

产品描述：

Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC₅₀ of 8.8 nM.¹ It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC₅₀ = 6 μM) and phosphatase 1B (IC₅₀ = 15 μM).¹ S32826 inhibits LPA release from adipocytes (IC₅₀ = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.¹

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