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产品描述:

产品名称:Human PD-1 / PDCD1 Protein

背景说明: Programmed Death-1 receptor (PD-1), also known as CD279, is type I transmembrane protein belonging to the CD28 family of immune regulatory receptors.PD1 is a inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self . Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation .

别名: hPD-1; PD-1; PD1hPD-1; PDCD1 ; CD279 antigen; CD279;programmed cell death 1; programmed cell death protein 1; Protein PD-1; SLEB2

Accession: Q8IX89

序列: Leu25-Gln167

种属: Human

来源: Recombinant Human PD1 Protein is expressed from mammalian with mFc at the C-terminal.;It contains Leu25-Gln167.

分子量: The Protein has a calculated MW of 41.6kDa. As a result of glycosylation, the protein migrates to64-68kDa based on Bis-Tris PAGE.

纯度: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

内毒素水平: Less than 1 EU per μg by the LAL method.

形态: Lyophilized from 0.22um filtered solution in PBS (pH 7.4).Normally 5 % trehalose is added as protectant before lyophilization.

储存/保存方法: The product should be stored at -70℃ or -20℃.

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