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产品描述:

产品名称:Human LILRA4 / CD85g Protein

背景说明: LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.

别名: CD85 antigen-like family member G; CD85g antigen; CD85g; ILT7; ILT-7; ILT7MGC129598; Immunoglobulin-like transcript 7; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member4; LILRA4; MGC129597

Accession: P59901

序列: [Native SP]Glu24-Asn446<His-avi>

种属: Human

来源: Human LILRA4 Protein is expressed from mammalian with His and Avi Tag at the C-terminal.;It contains Glu24-Asn446.

分子量: The protein has a predicted MW of 49.5 kDa .Due to glycosylation, the protein migrates to 60-75 KDabased on Bis-Tris PAGE result.

纯度: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

内毒素水平: Less than 1 EU per μg by the LAL method.

形态: Lyophilized from 0.22um filtered solution in PBS (pH 7.4).Normally 5 % trehalose is added as protectant before lyophilization.

储存/保存方法: The product should be stored at -70℃ or -20℃.

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