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产品描述:

产品名称:Human IGF1R / CD221 Protein

别名: CD221 antigen; CD221; EC 2.7.10; EC 2.7.10.1; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGF-IR; IGFR; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; soluble IGF1R variant 1; soluble IGF1R variant 2

背景说明: IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta  subunits. Both the alpha  and beta  subunits are encoded within a single receptor precursor cDNA. Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.

序列: Met1-Asn932

Accession: P08069

种属: Human

来源: Recombinant Human IGF1R Protein is expressed from mammalian with a poly-His and Avi tag atthe C-terminal.;It contains Met1-Asn932 .

分子量: The Protein has a calculated MW of 81 kDa (alpha subunit) and 23 kDa (beta subunit) .As a resultof glycosylation, the protein migrates to 110-120kDa(alpha subunit) and 52-55KDa(beta subunit)based on Bis-Tris PAGE.

纯度: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

内毒素水平: Less than 1 EU per μg by the LAL method.

形态: Lyophilized from 0.22um filtered solution in PBS (pH 7.4).Normally 5 % trehalose is added as protectant before lyophilization.

储存/保存方法: The product should be stored at -70℃ or -20℃.

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