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产品描述:

产品名称:Human IL-23 alpha&IL-12 beta Protein

背景说明: The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.

别名: IL-23、IL-23A 、IL23 、 IL23P19 、 P19 、SGRF

序列: Met1 - Pro189 (IL-23 alpha) & Met1- Ser328(IL-12 beta)

Accession: Q9NPF7 (IL-23 alpha) & P29460 (IL-12 beta)

种属: Human

来源: Human IL-23 alpha&IL-12 beta Protein is expressed from Expi293 with a His and Avi Tag at the C-terminal.;It contains Met1 - Pro189 (IL-23 alpha) & Met1- Ser328(IL-12 beta) .

分子量: The protein has a predicted MW of 21.7 (IL-23 alpha) & 34.7 (IL-12 beta) kDa.Due to glycosylation,the protein migrates to 20 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) KDa based on Bis-TrisPAGE result.

纯度: > 95% as determined by Bis-Tris PAGE

内毒素水平: Less than 1 EU per μg by the LAL method.

形态: Lyophilized from 0.22um filtered solution in PBS (pH 7.4).Normally 5 % trehalose is added as protectant before lyophilization.

储存/保存方法: The product should be stored at -70℃ or -20℃.

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