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产品描述:

产品名称:Human Trem2 Protein

背景说明: TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily . Mature human TREM-2  consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.

别名: PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2triggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2

序列: His19-Ser174

Accession: Q9NZC2

种属: Human

来源: Recombinant Human Trem2 Protein is expressed from mammalian with His and Avi Tag at the C-terminal.;It contains His19-Ser174.

分子量: The protein has a predicted MW of 20.3 kDa. Due to glycosylation, the protein migrates to 30-45KDa based onBis-Tris PAGE result.

纯度: > 95% as determined by Bis-Tris PAGE;> 95% as determined by SEC-HPLC

内毒素水平: Less than 1 EU per μg by the LAL method.

形态: Lyophilized from 0.22um filtered solution in PBS (pH 7.4).Normally 5 % trehalose is added as protectant before lyophilization.

储存/保存方法: The product should be stored at -70℃ or -20℃.

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