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产品描述:

产品名称:RNA Polymerase III Inhibitor

别名: N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide

CAS号: 577784-91-9

描述: RNA Polymerase III Inhibitor is a cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III. The compound Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.

分子式: C₁₉H₁₅Cl₂N₃O₂S₂

密度: 1.53 g/cm³ (Predicted)

分子量: 452.37

熔点: 262.17° C (Predicted)

应用: An indazolo-sulfonamide compound displaying inhibitory activity against RNA Polymerase III

纯度: ≥97%

沸点: 632.33° C at 760 mmHg (Predicted)

SMILES: CC1=C(SC2=C1C=C(C=C2)Cl)C3=NN(C(=C3)NS(=O)(=O)C4=CC=CC=C4Cl)C

折射率: n²⁰_D 1.72 (Predicted)

IC50: RNA Polymerase III: IC₅₀ = 27 μM (human); RNA Polymerase III: IC₅₀ = 32 μM (S.cerevisiae)

储存/保存方法: Store at 4° C

形态: Solid

可溶性/溶解性: Soluble in DMSO (15 mg/ml).

PubChem CID: 2824289

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