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产品描述:

产品名称:L-Ascorbic Acid 2-phosphate (magnesium salt)

参考文献: 1.Gropper, S.S.,Smith, J.L. and Groff, J.L. The water-soluble vitamins. Advanced Nutrition and Human Metabolism 4, 259-275 (2005).
2.Kurata, S. and Hata, R. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. The Journal of Biological Chemisty 266(15), 9997-10003 (1991).
3.Yoshikawa, K.,Takahashi, S.,Imamura, Y., et al. Secretion of non-helical collagenous polypeptides of α1(IV) and α2(IV) chains upon depletion of ascorbate by cultured human cells. Journal of Biochemistry 129(6), 929-936 (2001).
4.Furue, M.K.,Na, J.,Jackson, J.P., et al. Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. Proceedings of the National Academy of Sciences of the United States of America 105(36), 13409-13414 (2008).
5.Kimoto, M.,Shima, N.,Yamaguchi, M., et al. Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate. Invest.Ophthalmol.Vis.Sci. 53(12), 7583-7589 (2012).
6.Kyll?nen, L.,Maimi, S.,Mannerstr?m, B., et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro. Stem Cell Res.Ther. 4(1), 1-15 (2013).
7.Fang, X.,Murakami, H.,Demura, S., et al. A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgery. PLoS One 9(2), 1-6 (2014).
8.Mariner, P.D.,Johannesen, E. and Anseth, K.S. Manipulation of miRNA activity accelerates osteogenic differentiation of hMSCs in engineered 3D scaffolds. J.Tissue Eng.Regen.Med. 6(4), 314-324 (2012).

CAS号: 113170-55-1

描述: L-Ascorbic acid (vitamin C; Item No. 14656) is essential for the synthesis of collagen, with deficiency resulting in scurvy.¹ Notably, humans and other primates, guinea pigs, and certain other animals lack an enzyme necessary for vitamin C synthesis.¹ L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture.^2,3 It may be included in media to enhance the survival of human embryonic stem cells or increase the growth and replicative lifespan of human corneal endothelial cells.^4,5 AA2P is also used to drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells.^6,7,8

别名: AA2P;Ascorbyl PM;Phospitan C;

分子式: C₆H₆O₉P ? 1.5Mg

分子量: 289.5

纯度: ≥95%

储存/保存方法: Store at -20℃

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