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产品描述:

产品名称:Recombinant human T-cell immunoglobulin mucin receptor 3 / TIM-3 protein

英文别名: T-cell immunoglobulin and mucin domain-containing protein 3 / TIMD-3 T-cell immunoglobulin mucin receptor 3 / TIM-3 T-cell membrane protein 3

描述:

 Recombinant human TIM3 protein aa1-201 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant TIM3 is 22.1 kDa. Purified TIM3 protein is between the position of 43-26 kDa on SDS-PAGE gel under reduced condition.
TIM3 protein is purified by proprietary chromatographic techniques.

Entrez Gene summary for TIM3:

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

UniProtKB/Swiss-Prot: Q8TDQ0 (HAVR2_HUMAN)

Function: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function.

Accession: NP_116171.3

中文别名: TIM-3蛋白

来源: Mammalian cells

形态: Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5。

储存/保存方法: Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws.

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