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产品描述:

产品名称:Recombinant Human Angiostatin

氨基酸序列: VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP

参考文献: 1.Takahashi S, Shinya T, Sugiyama A. 2010. J Pharmacol Sci, 112: 432-7.<br/>2.Frank KFandMuller-Ehmsen J. 2009. Heart, 95: 269-70.<br/>3.Perri SR, Annabi B, Galipeau J. 2007. FASEB J, 21: 3928-36.<br/>4.Kim KS, Kim HS, Park JS, et al. 2004. Cancer Gene Ther, 11: 441-9.<br/>5.Wahl ML, Owen CS, Grant DS. 2002. Endothelium, 9: 205-16.

Accession: <a href="http://www.uniprot.org/uniprot/P00747" target="_blank">P00747</a>

中文别名: Angiostatin蛋白

Gene IDs: <a href="http://www.ncbi.nlm.nih.gov/gene/5340" target="_blank">5340</a>

种属: Human

来源: Escherichia coli.

纯度: > 95 % by SDS-PAGE and HPLC analyses.

内毒素水平: Less than 1 EU/μg of Recombinant HumanAngiostatin as determined by LAL method.

活性: Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 × 10⁵ IU/mg.

形态: Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM NaAc, pH 5.5, 4 % mannitol.

溶解方法: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存/保存方法: This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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