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产品描述:

产品名称:SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, C-6His)

背景说明: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

英文别名: SARS-CoV-2 RBD Protein; SARS-CoV-2 Spike RBD Protein; SARS-CoV-2 S Protein RBD

描述: Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H) is expressed with a 6His tag at the C-terminus. G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y and Y505H mutations were identified in the SARS-CoV-2 variant (known as Omicron/B.1.1.529 lineage) which emerged in South Africa.

纯化方法: Affinity purification chromatography

来源: Human Cells

分子量: 26.2kDa AP Mol Mass: 32-40kDa, reducing conditions

纯度:  Greater than 95% as determined by reducing SDS-PAGE.

内毒素水平: Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test

形态: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

储存/保存方法: Reconstituted protein solution should be stored at  ≤ -20°C

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