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产品描述:

产品名称:Recombinant Human FGF-23

氨基酸序列: YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI

参考文献: 1.Smallwood PM, Munoz-Sanjuan I, Tong P, et al. 1996. Proc Natl Acad Sci U S A. 93:9850-7.<br/>2.Fu L, John LM, Adams SH, et al. 2004. Endocrinology. 145:2594-603.<br/>3.Kharitonenkov A, Shiyanova TL, Koester A, et al. 2005. J Clin Invest. 115:1627-35.<br/>4.Kurosu H, Kuro OM. 2009. Mol Cell Endocrinol. 299:72-8.<br/>5.Lin BC, Wang M, Blackmore C, et al. 2007. J Biol Chem. 282:27277-84.<br/>6.Kharitonenkov A, Dunbar JD, Bina HA, et al. 2008. J Cell Physiol. 215:1-7.<br/>7.Riminucci M, Collins MT, Fedarko NS, et al. 2003. J Clin Invest. 112:683-92.<br/>8.Shimada T, Hasegawa H, Yamazaki Y, et al. 2004. J Bone Miner Res. 19:429-35.

Accession: <a href="http://www.uniprot.org/uniprot/Q9GZV9" target="_blank">Q9GZV9</a>

中文别名: FGF-23蛋白

Gene IDs: <a href="http://www.ncbi.nlm.nih.gov/gene/8074" target="_blank">8074</a>

种属: Human

来源: Escherichia coli.

纯度: > 95 % by SDS-PAGE and HPLC analyses.

内毒素水平: Less than 1 EU/μg of Recombinant HumanFGF-23 as determined by LAL method.

活性: Fully biologically active when compared to standard. The ED₅₀ as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/ml, corresponding to a specific activity of > 2.0 × 10³ IU/mg in the presence of 0.3 µg/ml of rMuKlotho and 10 μg/ml of heparin.

形态: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

溶解方法: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存/保存方法: This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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