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试剂描述:

产品名称:人血管紧张素II

产品别名:血管紧张素 II ,人

CAS号:4474-91-3

英文别名:人血管紧张素II

分子量:1046.18

分子式:C₅₀H₇₁N₁₃O₁₂

纯度:98%

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保存方法:Store at -20° C

描述:

Angiotensin II plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K⁺ current in neurons and activates JAK2 in smooth muscle cells. Furthermore, angiotensin II activates FAK (p125FAK) and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. It also activates c-Src (p60c-src), ERK1/2, JNK, and p38α (p38 MAP Kinase) in vascular smooth muscle cells.

应用:A peptide involved in the regulation of blood pressure

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