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抑制剂描述:

产品名称:Riluzole hydrochloride

产品别名:见爱必信官网

英文别名:Riluzole hydrochloride

靶点:

CAS:850608-87-6

纯度:≥99%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na⁺ channels (ED₅₀ = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED₅₀ value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED₅₀ value of 4 mg/kg.¹ Riluzole has been explored as a therapeutic for slowing disease progression of amyotrophic lateral sclerosis.

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