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试剂描述:

产品名称:[4-(十四烷oyl氨基)苄基]磷酸

产品别名:

CAS号:1096770-84-1

英文别名:[4-(十四烷oyl氨基)苄基]磷酸

分子量:397.5

分子式:C₂₁H₃₆NO₄P

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20℃

描述:

Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC₅₀ of 8.8 nM.¹ It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC₅₀ = 6 μM) and phosphatase 1B (IC₅₀ = 15 μM).¹ S32826 inhibits LPA release from adipocytes (IC₅₀ = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.¹

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