公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

试剂描述:

产品名称:SR8278

产品别名:

CAS号:1254944-66-5

英文别名:SR8278

分子量:361.5

分子式:C₁₈H₁₉NO₃S₂

纯度:≥90%

外观:见爱必信官网

保存方法:Store at -20℃,2 years

描述:REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC₅₀ = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112 (Item No. 11931). Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.

应用:

产品信息订购:

产品更多信息请进入爱必信网站咨询