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产品描述:

产品名称:Human RGMa Protein

背景说明: Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis (EAE), which is the animal model of multiple sclerosis (MS).? RGM is expressed in pathogenic Th17 cells and induces neurodegeneration by binding to neogenin.

英文别名: Repulsive guidance molecule A、RGM domain family member A、RGMA

Accession: Q96B86

中文别名: RGMa蛋白

序列: Signal peptide:1 – 47

标签: C-His-Avi

种属: Human

来源: Recombinant Human RGMa Protein is expressed from mammalian with a His Tag and Avi Tag atthe C-terminal.;It contains Met 1-Pro 47.

分子量: The protein has a predicted MW of 44.5 kDa.Due to glycosylation, the protein migrates to 45-48KDa based on Bis-Tris PAGE result.

纯度: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

内毒素水平: Less than 1 EU per μg by the LAL method.

形态: Lyophilized from 0.22um filtered solution in PBS (pH 7.4).Normally 5 % trehalose is added as protectant before lyophilization.

储存/保存方法: The product should be stored at -70℃ or -20℃.

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