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产品描述:

产品名称:Emricasan

参考文献:

[1] Barreyro FJ, et al. Liver Int. 2015, 35(3):953-66.

[2] Xu M, et al. Nat Med. 2016, [Epub ahead of print].

靶点: caspase

CAS号: 254750-02-2

描述:

Emricasan is a potent irreversible <b>pan-caspase</b> inhibitor.

In vitro(体外研究): Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.

分子式: C₂₆H₂₇F₄N₃O₇

In vivo(体内研究): Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.

分子量: 569.50

纯度: 99.00 %

储存/保存方法: store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

可溶性/溶解性: 体外:
DMSO 100mg/mL(175.59mM)
Ethanol 100mg/mL(175.59mM)
Water <1mg/mL

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