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产品描述:

产品名称:Z-DEVD-FMK

参考文献:

[1] Rickers A, et al. Eur J Immunol. 1998, (1), 296-304.

[2] Yakovlev AG, et al. J Neurosci. 1997, 17(19), 7415-7424.

[3] Wang J, et al. J Card Fail. 2000, 6(3), 243-249.

[4] Meguro T, et al. Stroke. 2001, 32(2), 561-566.

[5] Kanthasamy AG, et al. Free Radic Biol Med. 2006, 41(10), 1578-1589.

靶点: Caspase-3

CAS号: 210344-95-9

描述:

Z-DEVD-FMK是一种特异性,不可逆的Caspase-3抑制剂,也能有效抑制caspase-6, caspase-7, caspase-8和caspase-10。

中文别名: Caspase-3 Inhibitor

外观: White to slightly brown solid

In vitro(体外研究): Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Z-DEVD-FMK (100μM) attenuates OxyHb-induced cell detachment, reduced caspase-2 and -3 activities, abolishes OxyHb-induced DNA ladders, and prevents OxyHb-induced cleavage of PARP in cultured brain microvessel endothelial cells. Z-DEVD-FMK (100 μM) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 μM.

分子式: C₃₀H₄₁FN₄O₁₂

In vivo(体内研究): Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery.

分子量: 668.66

纯度: 98%

储存/保存方法: store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

可溶性/溶解性: DMSO : 100 mg/mL (149.55 mM)

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