Z-LEHD-FMK, 210345-04-3-爱必信（上海）生物科技有限公司

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Z-LEHD-FMK, 210345-04-3

品牌：爱必信(absin)

产地：中国

货号：abs813893

cas：210345-04-3

价格： ￥4223/盒
发布日期： 2022-04-07
更新日期： 2025-09-19

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产地	中国
品牌	爱必信(absin)
货号	abs813893
英文名称	见爱必信官网
包装规格	1mg,5mg
纯度	98%%
CAS编号	210345-04-3
别名	Z-LEHD-FMK, 210345-04-3
是否进口	否

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产品描述:

产品名称:Z-LEHD-FMK

靶点: Caspase-9

CAS号: 210345-04-3

描述:

Z-LEHD-FMK is a specific and irreversible inhibitor of caspase-9 .

Caspase-9 is an initiator caspase and plays an important role in the mitochondrial death pathway. Caspase-9 is activated during programmed cell death and cleaves procaspase-7 and procaspase-3.

Z-LEHD-FMK is a specific and irreversible caspase-9 inhibitor. In HCT116 human colon cancer cell line and 293 human embryonic kidney cell line, Z-LEHD-FMK inhibited apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). These results suggested that TRAIL induced death through the mitochondrial pathway in some human cells. In a colony assay, Z-LEHD-FMK inhibited the reduction of colony growth of HCT116 induced by TRAIL. In normal human hepatocytes, Z-LEHD-FMK protected cells from TRAIL-induced apoptosis. These results suggested that a combination of Z-LEHD-FMK and TRAIL selectively killed cancer cells while protecting normal liver cells .

中文别名: Caspase-9 Inhibitor

外观: powder

分子式: C₃₂H₄₃FN₆O₁₀

In vivo(体内研究): In rats with focal ischemia/reperfusion, Z-LEHD-FMK improved neurological outcome by 63% and reduced infarction volume by 49%. In spinal cord trauma rat model, Z-LEHD-FMK reduced apoptotic cell count and protected neurons, myelin, axons, glia and intracellular organelles in the spinal cord.

分子量: 690.72

纯度: 98%

储存/保存方法: store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

可溶性/溶解性: Soluble in DMSO

产品信息订购:

产品货号	产品名称	规格	价格	大包装及货期
abs813893	Z-LEHD-FMK	1mg	4223.00	立即咨询
abs813893	Z-LEHD-FMK	5mg	9768.00	立即咨询

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