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产品描述:

产品名称:白屈菜酸

靶点: NF-κB,Caspase-1,Glutamate decarboxylase

CAS号: 99-32-1

描述:

Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. 

中文别名: Chelidonic acid;Jerva acid;Jervaic acid; γ-Pyrone-2;6-dicarboxylic acid

外观: Beige to brown powder

In vitro(体外研究): Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM. Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.

分子式: C₇H₄O₆

In vivo(体内研究): Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.

分子量: 184.10

纯度: >98%

储存/保存方法: Store at -20°C

产品用途: 科研试剂,用于有机合成。

可溶性/溶解性: DMSO :4 mg/mL (21.72 mM)

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