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试剂描述:

产品名称:4-氧代-1,4-二氢-[1,10]邻二氮杂菲-3-羧酸

产品别名:

CAS号:331830-20-7

英文别名:4-氧代-1,4-二氢-[1,10]邻二氮杂菲-3-羧酸

分子量:240.21

分子式:C₁₃H₈N₂O₃

纯度:98%

外观:见爱必信官网

保存方法:Store at -20° C,2 years

描述:1,4 DPCA is a selective and potent inhibitor of prolyl 4-hydroxylation (P4H) in vitro. It has been shown to Inhibit α-prolyl 4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. 1,4-DPCA has also been shown to inhibit asparaginyl-hydroxylase factor inhibiting HIF (FIH) and to be useful for controlling excess collagen deposition in pathological fibrosis.

应用:A selective and potent inhibitor of prolyl 4-hydroxylase

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