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试剂描述:

产品名称:Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)

产品别名:

CAS号:1678417-57-6

英文别名:Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)

分子量:4843.5

分子式:C₂₀₁H₃₃₄N₈₂O₅₅S₂

纯度:95%

外观:见爱必信官网

保存方法:-20°C,有效期2年。

描述:This chimeric peptide is a fragment derived from rabies virus glycoprotein (RVG). Because neurotropic viruses cross the blood-brain barrier to infect brain cells, the same strategy may be used to enter the central nervous system and deliver siRNA to the brain. To enable siRNA binding, this chimeric peptide was synthesized by adding nonamer arginine residues at the carboxy terminus of RVG. This RVG-9R peptide was able to bind and transduce siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier.

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