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试剂描述:

产品名称:ERK Inhibitor

产品别名:

CAS号:1049738-54-6

英文别名:ERK Inhibitor

分子量:328.8

分子式:C₁₄H₁₆N₂O₃S ? HCl

纯度:≥95%

外观:见爱必信官网

保存方法:Store at -20℃,2 years.

描述:ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (K_D = 5 µM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC₅₀ = 15-20 µM), A549 lung carcinoma cells (IC₅₀ = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

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