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试剂描述:

产品名称:二苯基硼酸-2-氨基乙酯

产品别名:2-氨基乙基二苯硼酸酯

CAS号:524-95-8

英文别名:二苯基硼酸-2-氨基乙酯

分子量:225.09

分子式:C₁₄H₁₆BNO

纯度:98%

外观:见爱必信官网

保存方法:Store at -20° C,2 years.

描述:2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca²⁺-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca²⁺entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.

应用:A TRP activator that also blocks IP3R

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