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试剂描述:

产品名称:佛波酯

产品别名:佛波酯; TPA;佛波醇12-十四酸酯13-乙酸酯;12-十四酸酯13-乙酸佛波醇酯;

CAS号:16561-29-8

英文别名:佛波酯

分子量:616.83

分子式:C₃₆H₅₆O₈

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20° C,3 years.

描述:

PMA(同义名:TPA)是一种广泛用于体内外实验的佛波酯(phorbol ester) PKC激活剂。PMA结合PKC(Ki =2.6 nM)并激活其功能,在细胞和组织中都呈现出极其广的抑制谱。PMA可以抑制Fas诱导的细胞凋亡,但又可以诱导HL-60细胞的凋亡。PMA是一种高效的肿瘤促进剂,可以促进小鼠皮肤瘤的形成。尽管PMA毒性较强,但是在人体内仍显示出抗白血病和抗中性白细胞减少的活性。 

PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca²⁺-ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

应用:A reversible and highly potent protein kinase C (PKC) activator

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