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抑制剂描述:

产品名称:2-cyano-Pyrimidine

产品别名:见爱必信官网

英文别名:2-cyano-Pyrimidine

靶点:Others

CAS:14080-23-0

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and subsequent derivatives are under study for the treatment of osteoperosis. Cathepsin K is a lysosomal cysteine protease found in osteoclasts. Elevated activity of this protease has been linked to the formation of osteoporosis and arthritis.

溶解性:DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

体外研究:

2-cyano-Pyrimidine was identified as a cathepsin K inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. Enzymatic study showed that 2-cyano-Pyrimidine had an IC50 value of 170 nM for inhibition of cathepsin K, elevated activity of which has been linked to the formation of osteoporosis and arthritis. Moreover, Cathepsin K was found to be a lysosomal cysteine protease found in osteoclasts.

体内研究:

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