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抑制剂描述:

产品名称:360A iodide

产品别名:见爱必信官网

英文别名:360A iodide

靶点:G-quadruplex

CAS:737763-37-0

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

溶解性:DMSO : 2 mg/mL (2.84 mM; Need ultrasonic)

体外研究:

360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.

体内研究:

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