公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

抑制剂描述:

产品名称:Acetaminophen

产品别名:见爱必信官网

英文别名:Acetaminophen

靶点:COX

CAS:103-90-2

纯度:99%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor.

溶解性:DMSO :15.1 mg/mL (100 mM)
Ethanol :15.1 mg/mL (100 mM)

体外研究:

In vitro, acetaminophen elicites a 4.4-fold selectivity toward COX-2 inhibition (IC50 113.7 μM for COX-1; IC50 25.8 μM for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions are 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remaine above the in vitro IC50 for COX-2 for at least 5 h postadministration. Ex vivo IC50 values (COX-1: 105.2 μM; COX-2: 26.3 μM) of acetaminophen compared favorably with its in vitro IC50 values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function is not achieved.MTT assay shows that Acetaminophen (APAP) in a dose of 50 mM significantly (p.

体内研究:Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p.

产品信息订购:

产品更多信息请进入爱必信网站咨询