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抑制剂描述:

产品名称:AdipoRon

产品别名:见爱必信官网

英文别名:AdipoRon

靶点:Adiponectin Receptor

CAS:924416-43-3

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with K_D of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.

溶解性:Ethanol :47 mg/mL (109.7 mM)
DMSO :80 mg/mL (186.7 mM)

体外研究:

AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes.

体内研究:In skeletal muscle and liver of wild-type mice AdipoRon (50 mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50 mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet.

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