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抑制剂描述:

产品名称:Atenolol

产品别名:见爱必信官网

英文别名:Atenolol

靶点:Adrenergic Receptor

CAS:29122-68-7

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Atenolol is a selective β1 receptor antagonist.

溶解性:DMSO :53 mg/mL (198.99 mM)
Ethanol :53 mg/mL (198.99 mM)
Water :35 mg/mL (131.41 mM)

体外研究:

体内研究:In clinical pharmacokinetics studies, atenolol is a hydrophilic betareceptor blocking drug, which is predominantly eliminated via the kidneys, only about 5% of the atenolol is metabolised by the liver. After oral administration atenolol is incompletely absorbed from the intestine, so about 50% of the beta blocker are finally biovailable. In plasma only 3% of atenolol are protein-bound. After oral administration elimination half life of atenolol is calculated from 6 to 9 h. There exists a linear relationship between the atenolol plasma levels and the degree of beta blocking effect measured by inhibition of the exercise-induced tachycardia while no correlation is found between plasma levels of atenolol and blood pressure lowering activity of the drug.

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