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抑制剂描述:

产品名称:AZD-5069

产品别名:见爱必信官网

英文别名:AZD-5069

靶点:CXCR

CAS:878385-84-3

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD.

溶解性:DMSO : 90 mg/mL (188.87 mM; Need ultrasonic)

体外研究:

AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of -IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye.

体内研究:

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