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抑制剂描述:

产品名称:BIX-01294

产品别名:见爱必信官网

英文别名:BIX-01294

靶点:Histone Methyltransferase

CAS:935693-62-2

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.

溶解性:H2O : 14.29 mg/mL (29.13 mM; Need ultrasonic)

体外研究:

BIX-01294 (4.1 μM) treatment of?G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes. BIX-01294 (5 μM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy. BIX-01294 (1 μg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.

体内研究:

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