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抑制剂描述:

产品名称:Chloramphenicol

产品别名:见爱必信官网

英文别名:Chloramphenicol

靶点:Antibacterial

CAS:56-75-7

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Chloramphenicol is a broad-spectrum antibiotic.

溶解性:Very soluble in water

体外研究:

Chloramphenicol results in a constitutive increase in the level of cspA transcript and constitutive production of CS7.4. Chloramphenicol down-regulates the mitochondrial DNA-encoded Cox I protein, but not nuclear-encoded proteins. Chloramphenicol increases cellular levels of the p21(waf1/cip1) protein and p21(waf1/cip1) mRNA through a p53-independent pathway. Chloramphenicol, at concentrations greater than 0.1 g/L (0.3 mM), inhibits the denitrifying enzyme activity (DEA) of slurries of humisol and sandy loam soils by disrupting the activity of existing nitrate reductase enzymes. Chloramphenicol, at concentrations from 5 mM to 2 mM initiates apoptosis in dividing cells from a monkey kidney-derived cell line and in haematopoietic progenitor cells from human neonatal cord blood. Chloramphenicol suppresses growth of progenitor cells.

体内研究:Chloramphenicol results in increased t1/2(beta) (by 209%), and decreased ClB (by 45%), and prolonged recovery indices (by 768 to 946%) in greyhounds. Chloramphenicol suppresses increases in the body weight and liver weight of experimental animals and at the same time induced a remarkable increase in lipid peroxidation in the liver during the formation of megamitochondria. Chloramphenicol-induced formation of megamitochondria is not simply ascribed to the suppression of the dividing process of mitochondria due to lowered protein synthesis in mitochondria but is intimately related to oxidative stress.

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