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抑制剂描述:

产品名称:CNQX

产品别名:见爱必信官网

英文别名:CNQX

靶点:AMPAR

CAS:115066-14-3

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

 CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。

溶解性:DMSO: ≥30 mg/mL

体外研究:

In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons.

体内研究:The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg.

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