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抑制剂描述:

产品名称:Cyclosporin A

产品别名:见爱必信官网

英文别名:Cyclosporin A

靶点:Others

CAS:59865-13-3

纯度:>99 %

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

CyclosporinA是一种免疫抑制剂,与亲环素结合,随后抑制calcineurin,无细胞试验中IC50为7nM,广泛用于预防器官移植反应中的排斥反应。

在T细胞中,CyclosporinA与亲环蛋白(免疫亲和素)结合,形成亲环蛋白-CyclosporinA复合体,其结合并抑制钙调磷酸酶。CyclosporinA抑制钙调磷酸酶,IC50是7nM,随后阻断NF-AT核转运。CyclosporinA通过抑制MTP(线粒体通透性转换孔)的开放而影响线粒体,IC50是39nM。

溶解性:DMSO:100 mg/mL warmed (83.15 mM)
Ethanol:100 mg/mL warmed (83.15 mM)

体外研究:

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. Cyclosporin A inhibits calcineurin with IC50 of 7 nM, then blocks the nuclear translocation of NF-AT. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM.

体内研究:Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. , is clinically used in organ transplantation to prevent rejection.

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