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抑制剂描述:

产品名称:D-AP5

产品别名:见爱必信官网

英文别名:D-AP5

靶点:iGluR

CAS:79055-68-8

纯度:99%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDA_R. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDA_R activity as compared to this (-)-isomer.

溶解性:Soluble in water (9 mg/ml), and 1 M NH4OH (50 mg/ml).

体外研究:

体内研究:D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze.

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