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抑制剂描述:

产品名称:Dihydromyricetin

产品别名:见爱必信官网

英文别名:Dihydromyricetin

靶点:Flavonoids

CAS:27200-12-0

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

溶解性:DMSO : ≥ 100 mg/mL (312.26 mM)

体外研究:

Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons.

体内研究:Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. LD50: Mice 1.41g/kg (i.p.)

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