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- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810172
- cas：89464-63-1
- 价格： ￥607/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-09-19
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810172 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 25mg,25mg,25mg,200mg,200mg,200mg,50mg,50mg,50mg,100mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 89464-63-1 |
| 别名 | 二甲基乙二酰氨基乙酸;DMOG;Dimethyloxallyl glycine, |
| 是否进口 | 否 |
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抑制剂描述: 产品名称:Dimethyloxaloylglycine(DMOG) 产品别名:见爱必信官网 英文别名:Dimethyloxaloylglycine(DMOG) 靶点:HIF CAS:89464-63-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). 溶解性:DMSO : 101.5 mg/mL (579.54 mM) 体外研究:
DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system.?DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. 体内研究:DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
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