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- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810526
- cas：1206711-16-1
- 价格： ￥882/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-09-19
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810526 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 10mg,10mg,10mg,10mg,25mg,25mg,25mg,25mg,50mg,50mg,50mg,50mg,100mg,100mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 1206711-16-1 |
| 别名 | DMH 1;DMH-1 |
| 是否进口 | 否 |
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抑制剂描述: 产品名称:DMH1 产品别名:见爱必信官网 英文别名:DMH1 靶点:ALK CAS:1206711-16-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. 溶解性:DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming) 体外研究:
DMH1 inhibits BMP signaling with IC50 of 100 nM, and selectively inhibits the BMP-induced Smad1/5/8 activation. DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. In addition, DMH1 as a BMP inhibitor, significantly reduces NSCLC cell growth, migration and invasion. 体内研究:DMH1 dorsalizes the embryonic axis without disrupting the angiogenic process in Zebrafish embryos. In proepicardial explants, DMH1 results in the greatest inhibition of epithelial sheet migration. DMH1 (5 mg/kg i.p.)attenuates xenograft lung tumor growth in mice bearing A549 xenograft.
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