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抑制剂描述:

产品名称:Ezatiostat

产品别名:见爱必信官网

英文别名:Ezatiostat

靶点:GST

CAS:168682-53-9

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Ezatiostat inhibits the enzyme, glutathione S-transferase P1-1, GSTP1-1 is a key regulatory protein that can signal the cell to either make more blood elements or if the cell is cancerous to die.This inhibition induces a dissociation of GST P1-1 from its complex with c-jun N-terminal kinase (JNK)/c-Jun and activates signaling pathways that lead to cell proliferation and differentiation of normal hematopoietic cells and apoptosis of malignant cells.It has shown significant clinical activityof ezatiostat, a glutathione S-transferase P1-1 inhibitor in clinical development for the treatment of low- to intermediate-risk MDS.

溶解性:DMSO : ≥ 100 mg/mL (188.80 mM)

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