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抑制剂描述:

产品名称:Ferrostatin-1

产品别名:见爱必信官网

英文别名:Ferrostatin-1

靶点:Ferroptosis

CAS:347174-05-4

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂,EC50为60 nM。

溶解性:DMSO : 26.2 mg/mL (100 mM)
Ethanol : 26.2 mg/mL (100 mM)

体外研究:

Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 μM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells.

体内研究:

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