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抑制剂描述:

产品名称:FLI-06

产品别名:见爱必信官网

英文别名:FLI-06

靶点:Notch

CAS:313967-18-9

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.

溶解性:DMSO : 43.9 mg/mL (100 mM)
Ethanol : 8.8 mg/mL (20 mM)

体外研究:

In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.

体内研究:FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos.

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