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抑制剂描述:

产品名称:GDC0994

产品别名:见爱必信官网

英文别名:GDC0994

靶点:ERK

CAS:1453848-26-4

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.

溶解性:DMSO 87 mg/mL (197.79 mM)
Ethanol 87 mg/mL (197.79 mM)

体外研究:

体内研究:In CD-1 mice, a 10 mg/kg oral dose of GDC-0994 is sufficient to achieve the desired target coverage for at least 8 h. Daily, oral dosing of GDC-0994 results in significant single-agent activity in multiple in vivo cancer models, including KRAS-mutant and BRAF-mutant human xenograft tumors in mice.

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